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AseptiQuik® series connector manufacturer CPC will launch its new ultra-compact MicroCNX™ series connector to the European market at BioProduction 2021 in Milan, Italy from November 9th to 11th. The MicroCNX connector is the first and urgently needed small-volume closed aseptic process that replaces tube welding in the biopharmaceutical industry. The MicroCNX connector will be exhibited in Hall 4 (Booth G64) together with the AseptiQuik product line.
"The MicroCNX connector is a key choice for a series of bioprocessing, cell therapy, and gene therapy workflows," said Troy Ostreng, senior product manager of CPC's biopharmaceutical business. "So far, cumbersome pipe welding has been the only method for aseptically closed connections to very small diameter pipes. The MicroCNX connector represents a huge innovation in the industry."
MicroCNX connectors are designed for small volume processes involving widely used 1.6 mm (1/16 inch), 2.4 mm (3/32 inch), and 3.2 mm (1/8 inch) pipes. This includes sampling, seed culture expansion and early cell culture processes, including shake flasks and shakers.
Tests have shown that using the new connector for aseptic connection is four times faster than an operator using a pipe welder. Multiply these numbers over the course of a year, and operational efficiency becomes obvious.
The simple three-step process of using MicroCNX connectors requires minimal training. The user only needs to "pinch-press-pull": 1) pinch to remove the protective cover; 2) snap the two halves of the connector together; and 3) pull out the protective film to start the flow. In contrast, pipe welding involves a dozen or more steps, and the challenges faced by the operator include manipulating the pipe welder in place, handling equipment maintenance, and requiring precise techniques to create a successful weld. With the MicroCNX solution, there is no risk of welding errors, welding machine failure or production delays due to downtime of welding equipment.
The use of sterile connectors eliminates the need to purchase, calibrate, verify and maintain tube welders, which can cost more than 12,700 Euros (15,000 USD) each. Manufacturers often require multiple welders, which can take up valuable space in the clean room. "MicroCNX connectors can help biopharmaceutical, cell and gene therapy manufacturers make the most of their existing clean room space," Ostreng points out.
MicroCNX connectors can be integrated into prefabricated piping components, so operators know where to connect-they don't need to guess, which supports current good manufacturing practices (cGMP). The size, weight and geometry of the new connector are also in line with the trend of compact automation equipment for cell expansion and other processes.
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